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- Title
Prospective, Double-Blind, Concurrent, Placebo-Controlled Clinical Trial of Intravenous Ribavirin Therapy of Hemorrhagic Fever with Renal Syndrome.
- Authors
Huggins, John W.; Hsiang, Chin Min; Cosgriff, Thomas M.; Guang, Mei Ying; Smith, Joseph I.; Wu, Zhen Ou; LeDuc, James W.; Zheng, Zhi Ming; Meegan, James M.; Wang, Qi Nan; Oland, Dwayne D.; Gui, Xi En; Gibbs, Paul H.; Yuan, Guang Hui; Zhang, Tian Ming
- Abstract
A prospective, randomized, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin (loading dose of 33 mg/kg, 16 mg/kg every 6 h for 4 days, and 8 rug/kg every 8 h for 3 days) was conducted in 242 patients with serologically confirmed hemorrhagic fever with renal syndrome (HFRS) in the People's Republic of China. Mortality was significantly reduced (sevenfold decrease in risk) among ribavirin-treated patients, when comparisons were adjusted for baseline risk estimators of mortality (P = .01; two-tailed). HFRS typically consists of five consecutive but frequently overlapping clinical phases. Only occurrence of oliguric phase and hemorrhage was associated with severity of clinical disease in the placebo group. Ribavirin therapy also resulted in a significant reduction in the risk ofentering the oliguric phase and experiencing hemorrhage. The only ribavirin-related side effect was a well-recognized, fully reversible anemia after completion of therapy.
- Publication
Journal of Infectious Diseases, 1991, Vol 164, Issue 6, p1119
- ISSN
0022-1899
- Publication type
Article