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- Title
Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis.
- Authors
Jen-Kuang Lee; I-Shun Wang; Chi-Hsien Huang; Yih-Fan Chen; Nien-Tsu Huang; Chih-Ting Lin
- Abstract
Coronary artery disease and its related complications pose great threats to human health. In this work, we aim to clinically evaluate a CMOS field-effect biomolecular sensor for cardiac biomarkers, cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and interleukin-6 (IL-6). The CMOS biosensor is implemented via a standard commercialized 0.35 μm CMOS process. To validate the sensing characteristics, in buffer conditions, the developed CMOS biosensor has identified the detection limits of IL-6, cTnI, and NT-proBNP as being 45 pM, 32 pM, and 32 pM, respectively. In clinical serum conditions, furthermore, the developed CMOS biosensor performs a good correlation with an enzyme-linked immuno-sorbent assay (ELISA) obtained from a hospital central laboratory. Based on this work, the CMOS field-effect biosensor poses good potential for accomplishing the needs of a point-of-care testing (POCT) system for heart disease diagnosis.
- Subjects
COMPLEMENTARY metal oxide semiconductors; BIOMOLECULAR electronics; HEART diseases; DIAGNOSIS; MYOCARDIAL infarction
- Publication
Sensors (14248220), 2017, Vol 17, Issue 12, p2733
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s17122733