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- Title
Green protocol for the synthesis of 1,8-dioxo-decahydroacridines by Hantzsch condensation using citric acid as organocatalyst.
- Authors
Patil, Monika; Karhale, Shrikrishna; Kudale, Ananada; Kumbhar, Arjun; More, Sagar; Helavi, Vasant
- Abstract
Herein we describe a clean and sustainable, one-pot, multi-component protocol for the synthesis of 1,8- dioxo-decahydroacridines by Hantzsch condensation of cyclic 1,3-dicarbonyl compound and NH4OAc with diverse aryl aldehydes using citric acid as an inexpensive green additive in ecological safe solvent. Utilization of cheaper and safer catalyst, cleaner reaction profile, straightforward work-up procedure and good to excellent yields of the desired product are the noteworthy aspects of this method.
- Subjects
SOLVENTS; CITRIC acid; CHEMICAL synthesis; CATALYSTS; RING formation (Chemistry)
- Publication
Current Science (00113891), 2019, Vol 116, Issue 6, p936
- ISSN
0011-3891
- Publication type
Article
- DOI
10.18520/cs/v116/i6/936-942