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- Title
Involvement of human seminal plasma inhibin, a multifunctional protein, in anti-HIV activity.
- Authors
Vernekar, Vandana; Velhal, Shilpa; Pereira, Jacintha; Bandivdekar, Atmaram
- Abstract
Body fluids of mammals, including semen, are increasingly recognized to harbour anti-microbial proteins which play a role in host defence against a myriad of pathogens. Human seminal plasma inhibin (hSPI) is reported to be a multifunctional protein, well-studied primarily for its fertility-related effects and recently for its anti-fungal activity. Therefore, it was thought worthwhile to study whether it also possesses anti-HIV activity. Towards this objective, human seminal plasma proteins were fractionated using gel-permeation chromatography and chromatofocusing. Results demonstrated that fraction-5 (containing purified hSPI) of the chromatofocused fractions demonstrated substantial anti-HIV activity. The data suggest that hSPI possesses anti-HIV activity. In future, molecular models based on such naturally occurring proteins could be potentially employed for prevention/ therapeutics for HIV/AIDS.
- Subjects
SEMINAL proteins; INHIBIN; GEL permeation chromatography; HIV infections; THERAPEUTICS; ANTI-HIV agents; AIDS treatment
- Publication
Current Science (00113891), 2014, Vol 107, Issue 5, p853
- ISSN
0011-3891
- Publication type
Article