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- Title
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review.
- Authors
Paula Frade, Virgínia; Soares Simões, Nathália; Baldoni Couto, Nayara Ragi; Sanches, Cristina; Di Lorenzo Oliveira, Cláudia
- Abstract
The present study aimed to review the existing literature and to evaluate the best dose regimen for benznidazole in adult patients with Chagas disease in the chronic phase. A systematic review was conducted followed by meta-analysis. Searches were performed in four databases, to include studies published until May 2019. The descriptors used were: "Chagas disease", "benznidazole", "Drug Therapy", "Pharmacokinetics", "Dose-response relationship, drug" and "Chronic disease". The meta-analysis compared studies using the standard dose of 5 mg/kg/day for 30 or 60 days. A total of 608 articles were found, 23 of which were considered eligible for this review and nine were included in the meta-analysis. The studies selected and analyzed were published between 1996 and 2018, with various benznidazole dose regimens, ranging from 2.5 mg/kg/day to 10 mg/kg/day, for 30 to 80 days of treatment. The results pointed to a great diversity of dose regimens, thus there is no consensus on the optimal dose regimen for benznidazole in the chronic phase of Chagas disease.
- Subjects
META-analysis; CHAGAS' disease; DRUG therapy; CHRONICALLY ill
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2020, Vol 62, p1
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/s1678-9946202062052err