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- Title
The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomized double-blind controlled trial.
- Authors
da Silva Paixão, Elemárcia Martins; de M. Oliveira, Ana Carolina; Pizato, Nathalia; Muniz-Junqueira, Maria Imaculada; Magalhães, Kelly G.; Yoshio Nakano, Eduardo; Ito, Marina K.; Paixão, Elemárcia Martins da Silva; Oliveira, Ana Carolina de M; Nakano, Eduardo Yoshio
- Abstract
<bold>Background: </bold>We evaluated the effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids enriched fish oil (FO) on nutritional and immunological parameters of treatment naïve breast cancer patients.<bold>Methods: </bold>In a randomized double blind controlled trial, the FO group (FG) patients were supplemented with 2 g/ day of FO concentrate containing 1.8 g of n-3 fatty acids during 30 days. The placebo group (PG) received 2 g/ day of mineral oil. At baseline and after the intervention, plasma levels of n-3 fatty acids, dietary intake, weight, body composition, biochemical and immunological markers were assessed.<bold>Results: </bold>At the end of the intervention period, no between group differences were observed regarding anthropometric parameters. There was a significant increase in the plasma phospholipid EPA (p = 0.004), DHA (p = 0.007) of the FG patients. In FG patients the percentages of peripheral blood CD4+ T lymphocytes and serum high sensitivity C-reactive protein (hsCRP) levels were maintained while in PG patients there was a significant increase in hsCRP (p = 0.024). We also observed a significant reduction in the percentage of CD4+ T lymphocytes in the peripheral blood (p = 0.042) of PG patients. No changes in serum proinflammatory cytokine and prostaglandin E2 levels were observed.<bold>Conclusions: </bold>Supplementation of newly diagnosed breast cancer patients with EPA and DHA led to a significant change in the composition of plasma fatty acids, maintained the level of CD4+ T cells and serum levels of hsCRP, suggestive of a beneficial effect on the immune system and less active inflammatory response.<bold>Trial Registration: </bold>Brazilian Clinical Trials Registry (REBEC): RBR-2b2hqh. Registered 29 April 2013, retrospectively registered.
- Subjects
EICOSAPENTAENOIC acid; DOCOSAHEXAENOIC acid; FISH oils in human nutrition; BREAST cancer treatment; PLACEBOS; OMEGA-3 fatty acids
- Publication
Nutrition Journal, 2017, Vol 16, p1
- ISSN
1475-2891
- Publication type
journal article
- DOI
10.1186/s12937-017-0295-9