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- Title
Importance of miRNA in SARS-CoV2 infection.
- Authors
Bautista De Sanctis, Juan; García, Alexis; Garmendia, Jenny; Moreno, Dolores; Hajduch, Marian; Radzioch, Danuta
- Abstract
At the end of 2019, a new pathogen, coronavirus SARS-CoV2, was identified. The virus has infected more than 30 million people worldwide with lethality close to 5 %. SARS-CoV2 is an RNA virus. The viral genome contains 29 891 nucleotides which encode 9 889 amino acids; 5'-replicase (orf1/ab) four main structural proteins [Spike (S) -Envelope (E) - Membrane (M) -Nucleocapsid (N)] and open reading frame proteins. MicroRNAs (miRNA) are potent posttranscriptional regulators of gene expression and hence can control viral infection and replication. In silico and bioinformatics assessments revealed that host miRNA (15b-5p, 15a-5p, 197-5p, 548c-5p, 548d-5p, 409-3p, 30b-5p, 505-3p) may be involved blocking viral replication. Also, viral miRNA are shared with cells miRNA (8066, 5197, 3611, 3934-3p, 1307-3p, 3691- 3p, 1468-5p), which may modulate cell response and facilitate SARS-CoV2 infection. Even though, these targets have to be validated with studies in vitro and in vivo, there is a high therapeutic potential involved which has been proposed and tested in other viral infections. More studies on the molecular mechanism of this complex viral infection are required to understand viral pathogenesis.
- Subjects
MICRORNA; PATHOGENIC microorganisms; AMINO acids; CYTOSKELETAL proteins; VIRAL replication
- Publication
Gaceta Médica de Caracas, 2020, Vol 128, pS17
- ISSN
0367-4762
- Publication type
Article
- DOI
10.47307/GMC.2020.128.s1.3