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- Title
Prevalence of human leukocyte antigen HLA-B*57:01 in individuals with HIV in West and Central Africa.
- Authors
Kolou, Malewe; Poda, Armel; Diallo, Zelica; Konou, Esther; Dokpomiwa, Tatiana; Zoungrana, Jacques; Salou, Mounerou; Mba-Tchounga, Lionèle; Bigot, André; Ouedraogo, Abdoul-Salam; Bouyout-Akoutet, Marielle; Ekouevi, Didier K.; Eholie, Serge P.
- Abstract
Background: The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*57:01 prevalence in individuals with HIV-1 in Africa. This study aimed to estimate HLA-B*57:01 prevalence in individuals with HIV-1 in West and Central Africa. Methods: A cross-sectional study was conducted in four countries in West and central Africa (Burkina-Faso, Côte d'Ivoire, Gabon, and Togo) from January 2016 to February 2020 to determine the status of HLA-B*57:01 in adults with HIV-1. The presence of HLA-B*57:01 was determined by using Single Specific Primer-Polymerase Chain Reaction (SSP-PCR) in blood samples. Prevalence rates were stratified based on country. Results: A total of 4016 (69.8% women) individuals with HIV were enrolled. Their median age was 45, and the interquartile range was 38–52. We included 500 (12.4%) patients in Burkina-Faso, 1453 (36.2%) in Côte d'Ivoire, 951 (23.7%) in Gabon, and 1112 (27.7%) in Togo. The overall HLA-B*57:01 prevalence was 0.1% [95% CI: 0.0–0.2%]. The prevalence of HLA-B*57:01 was similar according to the four countries. Only one case was reported in each country except Togo, with no cases. Conclusions: HLA-B*57:01 prevalence is low in individuals with HIV in West and central Africa, and there is no difference among countries. This study does not confirm the utility of HLA-B*57:01 allele testing for abacavir use in this region.
- Subjects
TOGO; AFRICA; BURKINA Faso; HLA histocompatibility antigens; HIV; ADULTS; ABACAVIR; HIV infections
- Publication
BMC Immunology, 2021, Vol 22, Issue 1, p1
- ISSN
1471-2172
- Publication type
Article
- DOI
10.1186/s12865-021-00427-7