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- Title
Bacterial cell division: experimental and theoretical approaches to the divisome.
- Authors
BROUGHTON, CLAIRE E.; ROPER, DAVID I.; VAN DEN BERG, HUGO A.; RODGER, ALISON
- Abstract
Cell division is a key event in the bacterial life cycle. It involves constriction at the midcell, so that one cell can give rise to two daughter cells. This constriction is mediated by a ring composed of fibrous multimers of the protein FtsZ. However, a host of additional factors is involved in the formation and dynamics of this "Z-ring" and this complicated apparatus is collectively known as the "divisome". We review the literature, with an emphasis on mathematical modelling, and show how such theoretical efforts have helped experimentalists to make sense of the at times bewildering data, and plan further experiments.
- Subjects
CELL division; BACTERIAL cells; FTSZ protein; CELL membranes; BACTERIAL genetics; ESCHERICHIA coli; GRAM-negative aerobic bacteria; CYTOKINESIS; BACTERIA
- Publication
Science Progress, 2015, Vol 98, Issue 4, p313
- ISSN
0036-8504
- Publication type
Article
- DOI
10.3184/003685015X14461391862881