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- Title
Incorporating first trimester analytes to predict delivery of a large for gestational infant in women with impaired glucose tolerance.
- Authors
Gabbay-Benziv, Rinat; Esin, Sertac; Baschat, Ahmet A.
- Abstract
Aim: To investigate first trimester maternal characteristics of women with impaired glucose tolerance that deliver large for gestational age (LGA) infants. Methods: Nested analysis from a prospective study of singleton pregnancies enrolled at first trimester. We studied women with an abnormal 1 h glucose challenge test that had normal follow-up oral glucose tolerance testing. Maternal characteristics, ultrasound parameters and serum analytes were stratified by subsequent delivery of an LGA infant. Parameters identified as significant on univariate analysis were used for a derivation of prediction by logistic regression. Odds ratio and prediction performance was determined using receiver operator curve (ROC) statistics. Results: A total of 33/114 (28.9%) women meeting the criteria delivered LGA infants. Maternal height (cm), and first trimester pregnancy-associated protein-A and free β-hCG (MoM) predicted delivery of an LGA infant (ROC area under curve 0.73; 95% CI 0.63-0.83). At a cutoff value of 0.172 the prediction rule achieved 91% sensitivity, 44% specificity, 41% positive predictive and 92% negative predictive value. Conclusion: Maternal height and first trimester high free β-hCG and PAPP-A levels may be used as predictors for delivery of LGA infants in women with impaired glucose tolerance.
- Subjects
MARYLAND; BIRTH size; CHORIONIC gonadotropins; CONFIDENCE intervals; GESTATIONAL diabetes; GOODNESS-of-fit tests; LONGITUDINAL method; METROPOLITAN areas; FIRST trimester of pregnancy; RISK assessment; STATISTICS; ULTRASONIC imaging; LOGISTIC regression analysis; BODY mass index; PREDICTIVE tests; RECEIVER operating characteristic curves; GLUCOSE intolerance; DATA analysis software; DESCRIPTIVE statistics; DISEASE complications; DISEASE risk factors
- Publication
Journal of Perinatal Medicine, 2015, Vol 43, Issue 3, p299
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2014-0041