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- Title
Screening of Selected Stingless Bee Honey Varieties for ACE2-Spike Protein-Binding Inhibition Activity: A Potential Preventive Medicine Against SARS-Cov-2 Infection.
- Authors
ARUNG, Enos Tangke; RAMADHAN, Rico; Mandzilkh, Liidza Diana; SANTOSO, Prasetia Aktavinaldy; Masako Matsumoto; Maki NAGATA; Kusuma, Irawan Wijaya; PARAMITA, Swandari; SUKEMI; YADI; Naomichi TAKEMOTO; AMEN, Yhiya; SYAFRIZAL; Kuniyoshi SHIMIZU; TANDIROGANG, Nataniel
- Abstract
The broader objective of this study is to identify natural materials that might inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We have focused on stingless bee honey, which has a unique taste that is both sweet and sour and sometimes bitter. We screened 12 samples of honey from 11 species of stingless bees using an angiotensin-converting enzyme 2 (ACE2)-spike protein-binding assay and phytochemical analysis. Ten of the samples showed inhibition above 50% in this assay system. Most of the honey contained tannins, alkaloids, flavonoids, triterpenoids, carotenoids and carbohydrates. Our findings in this in vitro study showed that honey from stingless bees may have a potent effect against SARS-CoV-2 infection by inhibiting the ACE2-spike protein-binding.
- Subjects
HONEY analysis; THERAPEUTIC use of honey; IN vitro studies; COVID-19; BIOLOGICAL products; PHYTOCHEMICALS; DESCRIPTIVE statistics
- Publication
Malaysian Journal of Medical Sciences, 2022, Vol 29, Issue 5, p146
- ISSN
1394-195X
- Publication type
Article
- DOI
10.21315/mjms2022.29.5.15