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- Title
Apo and InsP<sub>3</sub>-bound crystal structures of the ligand-binding domain of an InsP<sub>3</sub> receptor.
- Authors
Lin, Chun-Chi; Baek, Kyuwon; Lu, Zhe
- Abstract
We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate receptor (InsP3R) in its apo and InsP3-bound conformations. Comparison of these two conformations reveals that LBD's first ?-trefoil fold (?-TF1) and armadillo repeat fold (ARF) move together as a unit relative to its second ?-trefoil fold (?-TF2). Whereas apo LBD may spontaneously transition between gating conformations, InsP3 binding shifts this equilibrium toward the active state.
- Subjects
LIGAND binding (Biochemistry); CRYSTALS; INOSITOL; PHOSPHATES; SUGARS
- Publication
Nature Structural & Molecular Biology, 2011, Vol 18, Issue 10, p1172
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2112