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- Title
The Effect of Agomelatine on the Nociceptive System.
- Authors
Kivrak, Yuksel; Karademir, Basaran; Aygun, Hayati; Ersan, Yusuf; Ari, Mustafa; Karaahmet, Elif; Yagci, Ibrahim
- Abstract
Objective: The aim of the study was to study the effects of agomelatine, an antidepressant, on the nociceptive system. Methods: Twenty four male Swiss albino mice (four months old and 28.8±1.18 g average weight) were randomly divided into three groups, which were equal in numbers; Group A and B were the experimental groups and group C was the control group. Group A was given 12.5 mg/kg of agomelatine, Group B was given 25 mg/kg agomelatine and Group C was given physiological saline via intraperitoneal injection. To evaluate the nociceptive effects, by using the hot plate method (50°C), pain threshold values of the control and agomelatine groups were recorded as the 30th and 60th minute findings. Results: According to the pain threshold results, the datafor the two agomelatine groups were found to be higher than control group at both time points. In 30th minute measurements, between Group B and the other groups, significant differences were observed (p=0.007). In addition, significance in the interaction between time and group was observed (p=0.036). Conclusions: The results of the study suggest that agomelatine might have analgesic efficacy on the nociceptive system in mice.
- Subjects
ANTIDEPRESSANTS; HYPERALGESIA treatment; NOCICEPTORS; DRUG efficacy; PAIN threshold
- Publication
Klinik Psikofarmakoloji Bulteni, 2014, Vol 24, Issue 3, p220
- ISSN
1017-7833
- Publication type
Article
- DOI
10.5455/bcp.20130925022745