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- Title
A mechanistic theory to explain the efficacy of antiretroviral therapy.
- Authors
Laskey, Sarah B.; Siliciano, Robert F.
- Abstract
In the early years of the AIDS epidemic, a diagnosis of HIV-1 infection was equivalent to a death sentence. The development of combination antiretroviral therapy (cART) in the 1990s to combat HIV-1 infection was one of the most impressive achievements of medical science. Today, patients who are treated early with cART can expect a near-normal lifespan. In this Opinion article, we propose a fundamental theory to explain the mechanistic basis of cART and why it works so well, including a model to assess and predict the efficacy of antiretroviral drugs alone or in combination.
- Subjects
AIDS; HIV infections; ANTIRETROVIRAL agents; EPIDEMICS; MEDICAL sciences
- Publication
Nature Reviews Microbiology, 2014, Vol 12, Issue 11, p772
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro3351