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- Title
Novel vaccine vectors for HIV-1.
- Authors
Barouch, Dan H.; Picker, Louis J.
- Abstract
The ultimate solution to the global HIV-1 epidemic will probably require the development of a safe and effective vaccine. Multiple vaccine platforms have been evaluated in preclinical and clinical trials, but given the disappointing results of clinical efficacy studies so far, novel vaccine approaches are needed. In this Opinion article, we discuss the scientific basis and clinical potential of novel adenovirus and cytomegalovirus vaccine vectors for HIV-1 as two contrasting but potentially complementary vector approaches. Both of these vector platforms have demonstrated partial protection against stringent simian immunodeficiency virus challenges in rhesus monkeys using different immunological mechanisms.
- Subjects
AIDS vaccines; HIV prevention; ADENOVIRUSES; CYTOMEGALOVIRUSES; SIMIAN immunodeficiency virus
- Publication
Nature Reviews Microbiology, 2014, Vol 12, Issue 11, p765
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro3360