We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Listeria monocytogenes — from saprophyte to intracellular pathogen.
- Authors
Freitag, Nancy E.; Port, Gary C.; Miner, Maurine D.
- Abstract
Listeria monocytogenes is a bacterium that lives in the soil as a saprophyte but is capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. Recent studies suggest that L. monocytogenes mediates its saprophyte-to-cytosolic-parasite transition through the careful modulation of the activity of a virulence regulatory protein known as PrfA, using a range of environmental cues that include available carbon sources. In this Progress article we describe the regulation of PrfA and its role in the L. monocytogenes transition from the saprophytic stage to the virulent intracellular stage.
- Subjects
LISTERIA monocytogenes; PLANT physiology; PLANT ecology; SAPROPHYTES; PATHOGENIC microorganisms; INTRACELLULAR pathogens
- Publication
Nature Reviews Microbiology, 2009, Vol 7, Issue 9, p623
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2171