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- Title
Guanosine in a Single Stranded Region of Anticodon Stem-Loop tRNA Models is Prone to Oxidatively Generated Damage Resulting in Dehydroguanidinohydantoin and Spiroiminodihydantoin Lesions.
- Authors
Tomaszewska ‐ Antczak, Agnieszka; Guga, Piotr; Nawrot, Barbara; Pratviel, Geneviève
- Abstract
Oxidation of RNA hairpin models corresponding to anticodon stem-loop (ASL) of transfer RNA led to RNA damage consisting solely of a unique loop guanine oxidation. Manganese porphyrin/oxone treatment of RNA resulted in dehydroguanidinohydantoin ( DGh; major) and/or spiroiminodihydantoin ( Sp) lesions. Ribose damage was not observed. This two-electron transfer oxidation reaction allowed the identification of guanine oxidation products for further study of RNA species carrying a unique lesion at a single G to investigate their biological impact.
- Subjects
GUANOSINE; TRANSFER RNA; OXIDATION of DNA; HAIRPIN (Genetics); MANGANESE porphyrins
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 17, p6381
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201406409