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- Title
Absolute Asymmetric Synthesis: Protected Substrate Oxidation.
- Authors
Olsson, Susanne; Björemark, Per Martin; Kokoli, Theonitsa; Sundberg, Jonas; Lennartson, Anders; McKenzie, Christine J.; Håkansson, Mikael
- Abstract
Three new conglomerates incorporating bidentate sulfide ligands coordinated by RuII centers have been prepared. Total spontaneous resolution by slow crystallization gives highly enantioenriched crystal batches, which are used in enantioselective oxidation of the sulfide ligands to give chiral sulfoxide complexes with >98 % ee. All relevant stereoisomers have been characterized by single-crystal X-ray diffraction, CD spectroscopy, and chiral HPLC. If the ligand range can be extended to monodentate sulfides, a large-scale and recyclable process for enantioselective oxidation of sulfides can be designed.
- Subjects
ASYMMETRIC synthesis; BIOCHEMICAL substrates; OXIDATION; CONGLOMERATE; SULFIDE crystals; SPECTROMETRY; ENANTIOSELECTIVE catalysis
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 13, p5211
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201406354