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- Title
Effectiveness of nirmatrelvir‐ritonavir on severe outcomes of COVID‐19: A meta‐regression analysis.
- Authors
Chen, I‐Wen; Yu, Ting‐Sian; Lin, Chien‐Hung; Hung, Kuo‐Chuan
- Abstract
A recent meta-analysis published in the Journal of Medical Virology evaluated the effectiveness of the oral antiviral nirmatrelvir-ritonavir (NR) in high-risk COVID-19 patients. The analysis included 32 studies and found that NR was significantly effective in reducing mortality, hospitalizations, and disease progression compared to standard care, even in highly vaccinated populations with the Omicron variant. However, subgroup analysis indicated that NR was less effective against mortality in vaccinated/boosted patients. Additional meta-regression analyses showed that variations in vaccination coverage did not significantly affect the effectiveness of NR on these outcomes. These findings support the use of NR as a treatment option for high-risk patients.
- Subjects
COVID-19; COVID-19 pandemic; VACCINATION coverage; SARS-CoV-2 Omicron variant; VACCINATION status
- Publication
Journal of Medical Virology, 2024, Vol 96, Issue 6, p1
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.29718