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- Title
SUBCLONAL HETEROGENEITY DRIVING PROGRESSION AND TRANSFORMATION IN CHRONIC LYMPHOCYTIC LEUKEMIA.
- Authors
Campo, E.
- Abstract
Single cell RNA sequencing of CLL has revealed three major clusters characterized by different expression of I CXCR4 i , I CD27 i and I MIR155HG i , respectively, which may represent the recirculation of CLL cells between peripheral blood and lymph node. Novel single cell technologies allow the analysis of the transcriptome and (epi)genomic features of tumors and their evolution with an unprecedented resolution. The evolution of lymphoid neoplasms may be driven by their heterogeneous subclonal composition and competition, selection, and expansion of the different tumor cell subpopulations.
- Subjects
CHRONIC lymphocytic leukemia; RICHTER syndrome; HETEROGENEITY; B cell lymphoma; GENE expression
- Publication
Hematological Oncology, 2023, Vol 41, p38
- ISSN
0278-0232
- Publication type
Article
- DOI
10.1002/hon.3163_12