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- Title
Interpretation of interleukin-2 receptor alpha positive cells during induction chemotherapy for adult acute myelogenous leukaemia patients.
- Authors
Min, Woo-Sung; Kim, Hee-Je; Choi, Young; Jeong, Hye-Young; Kim, Chun-Choo
- Abstract
To correlate clinical outcomes with the expression of interleukin-2 receptor alpha (CD25) positive cells during induction chemotherapy (IC) in adult patients with acute myeloid leukaemia (AML), we investigated the prognostic importance of subsets of peripheral blood (PB) CD45+CD25+ cells. Seventy-five patients with newly diagnosed AML received the same initial IC; and serial PB samples were taken. The gated CD45/CD25 cell populations were used to compare the intensity of immunophenotypic signals based on the treatment timeline. Patients who responded poorly to IC demonstrated exceptionally higher levels of PB CD45+CD25+ cells by percentage ( p = 0.003) or by absolute count ( p = 0.046) on the seventh day (D + 7) of initial IC. In addition, patients in complete remission (CR) ( n = 61) demonstrated relatively lower levels of steady PB CD45+CD25+ after standard IC. These results suggest that the expression of CD25 can be used to predict the response to IC during an early period of treatment. Copyright © 2007 John Wiley & Sons, Ltd.
- Publication
Hematological Oncology, 2007, Vol 25, Issue 2, p76
- ISSN
0278-0232
- Publication type
Article
- DOI
10.1002/hon.807