We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Quantification of GABA concentration measured noninvasively in the human posterior cingulate cortex with 7 T ultra‐short‐TE MR spectroscopy.
- Authors
Genovese, Guglielmo; Deelchand, Dinesh K.; Terpstra, Melissa; Marjańska, Małgorzata
- Abstract
Purpose: The increased spectral dispersion achieved at ultra‐high field permits quantification of γ‐aminobutyric acid (GABA) concentrations at ultra‐short‐TE without editing. This work investigated the influence of spectral quality and different LCModel fitting approaches on quantification of GABA. Additionally, the sensitivity with which cross‐sectional and longitudinal variations in GABA concentrations can be observed was characterized. Methods: In ‐ vivo spectra were acquired in the posterior cingulate cortex of 10 volunteers at 7 T using a STEAM sequence. Synthetically altered spectra with different levels of GABA signals were used to investigate the reliability of GABA quantification with different LCModel fitting approaches and different realizations of SNR. The synthetically altered spectra were also used to characterize the sensitivity of GABA quantification. Results: The best LCModel fitting approach used stiff spline baseline, no soft constraints, and measured macromolecules in the basis set. With lower SNR, coefficients of variation increased dramatically. Longitudinal and cross‐sectional variations in GABA of 10% could be detected with 79 and 48 participants per group, respectively. However, the small cohort may bias the calculation of the coefficients of variation and of the sample size that would be needed to detect variations in GABA. Conclusion: Reliable quantification of normal and abnormal GABA concentrations was achieved for high quality 7 T spectra using LCModel fitting.
- Subjects
CINGULATE cortex; GABA; SPECTROMETRY; SAMPLE size (Statistics)
- Publication
Magnetic Resonance in Medicine, 2023, Vol 89, Issue 3, p886
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.29514