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- Title
Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3- a ]quinolines and 1,3,4-Oxadiazole Rings.
- Authors
Aksenov, Alexander V.; Kirilov, Nikita K.; Aksenov, Nicolai A.; Aksenov, Dmitrii A.; Sorokina, Elena A.; Lower, Carolyn; Rubin, Michael
- Abstract
Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-a]quinolines with 1,3,4-oxadiazole substituents.
- Subjects
NITROALKANES; ANNULATION; POLYPHOSPHORIC acid; QUINOLINE; HYDRAZINES; ELECTROPHILES; THIADIAZOLES
- Publication
Molecules, 2021, Vol 26, Issue 18, p5692
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26185692