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- Title
Development of a Telescoped Flow Process for the Safe and Effective Generation of Propargylic Amines.
- Authors
Donnelly, Kian; Zhang, Huan; Baumann, Marcus; Palmieri, Alessandro
- Abstract
Propargylic amines are important multifunctional building blocks that are frequently exploited in the synthesis of privileged heterocyclic entities. Herein we report on a novel flow process that achieves the safe and effective on-demand synthesis of propargylic amines in a telescoped manner. This process minimizes exposure to hazardous azide intermediates and renders a streamlined route into these building blocks. The value of this approach is demonstrated by the rapid generation of a small selection of drug-like thiazolines that result from a high-yielding reaction cascade between propargylic amines with different aryl isothiocyanates.
- Subjects
THIAZOLINES; AMINE synthesis; FORMYLATION; ISOTHIOCYANATES; REPRODUCTION; FLOW chemistry
- Publication
Molecules, 2019, Vol 24, Issue 20, p3658
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24203658