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- Title
Four New Furostanol Saponins from the Rhizomes and Roots of Smilax scobinicaulis and Their Cytotoxicity.
- Authors
Jing Xu; Shixiu Feng; Qi Wang; Yingli Cao; Miao Sun; Cunli Zhang
- Abstract
Four new furostanol saponins 1-4, along with two known furostanol saponins 5 and 6 and one known spirostanol saponin 7 were isolated from the rhizomes and roots of Smilax scobinicaulis. The structures of the new saponins were elucidated as 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one-3-O-α- L-arabinopyranosyl-(1-6)-β-D-glucopyranoside (1), 26-O-β-D-glucopyranoside-3β,26- dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one (2), 26-O-β-D-glucopyranoside-3β,26- dihydroxy-(25R)-5α-furostan-20(22)-en-6-one (3), 26-O-β-D-glucopyranoside-3β,23,26- trihydroxy-(23R, 25R)-5α-furostan-20(22)-en-6-one (4) on the basis of spectroscopic analysis. The isolated saponins were evaluated for cytotoxic activity against two human cancer cell lines including Hela (cervical carcinoma) and SMMC-7221 (hepatocellular carcinoma). Compounds 1 and 7 demonstrated cytotoxicity against the tested cell lines.
- Subjects
FUROSTANOL; QUILLAJA; CYTOTOXINS; MEDICINAL plants; SMILAX; SMILACACEAE
- Publication
Molecules, 2014, Vol 19, Issue 12, p20975
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules191220975