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- Title
Effects of 5 % weight loss through diet or diet plus exercise on cardiovascular parameters of obese: a randomized clinical trial.
- Authors
Fayh, Ana; Lopes, André; Silva, Antônio; Reischak-Oliveira, Álvaro; Friedman, Rogério
- Abstract
Objective: To evaluate the effects of 5 % weight loss, through diet only or diet plus exercise, on lipid profile, inflammation and endothelial function in obese individuals. Methods: In this randomized clinical trial, 48 obese individuals were randomized to either a diet only group (DI) or a diet and exercise group (DI + EXE). Treatment was maintained until 5 % of the initial body weight was lost. At baseline and upon completion, the following parameters were analyzed: total cholesterol and fractions, triglycerides, fibrinogen, von Willebrand factor, high-sensitive C-reactive protein (hs-CRP) and endothelial function (brachial artery flow-mediated vasodilation-FMD). Results: Thirteen individuals dropped out before completing the weight loss intervention. The median time required for reduction of 5 % of initial body weight was 79.7 days for the DI group and 65.9 days for the DI + EXE group ( P = 0.16). In both DI ( n = 18) and DI + EXE ( n = 17), total cholesterol (−15.8 ± 4.8 and −10.5 ± 4.9 mg/dL, respectively), triglycerides (−33.8 ± 10.0 and −39.4 ± 10.3 mg/dL, respectively) and hs-CRP (−1.35 ± 0.41 and −0.45 ± 0.43 mg/L, respectively) decreased significantly, and in a similar response (repeated measures ANOVA). Weight loss did not change significantly the fibrinogen and FMD in both groups. Conclusion: A 5 % weight loss improves lipid profile and reduces inflammation in obese individuals. Endothelial function did not change significantly. Weight loss has a significant impact on these cardiovascular risk factors, and this is independent of physical training.
- Subjects
CARDIOVASCULAR disease prevention; INFLAMMATION treatment; OBESITY treatment; ANALYSIS of covariance; ANALYSIS of variance; VASODILATION; BODY weight; C-reactive protein; CHI-squared test; CHOLESTEROL; CLINICAL trials; COMBINED modality therapy; ENDOTHELIUM; EXERCISE; EXERCISE physiology; FIBRINOGEN; HIGH density lipoproteins; LOW density lipoproteins; REDUCING diets; STATISTICS; STATURE; T-test (Statistics); TRIGLYCERIDES; WEIGHT loss; DATA analysis; BRACHIAL artery; RANDOMIZED controlled trials; REPEATED measures design; WAIST-hip ratio; EXERCISE intensity; DATA analysis software; DESCRIPTIVE statistics
- Publication
European Journal of Nutrition, 2013, Vol 52, Issue 5, p1443
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-012-0450-1