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- Title
Association of XRCC1 polymorphisms with arsenic methylation.
- Authors
Fujihara, Junko; Yasuda, Toshihiro; Iwata, Hisato; Tanabe, Shinsuke; Takeshita, Haruo
- Abstract
The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population ( n = 100). Individuals with genotype AA in p.Pro206Pro showed significantly higher urinary monomethylarsonic acid (MMA) and lower dimethylarsinic acid (DMA)/MMA ratio than genotype AG. As for p.Arg399Gln, both Arg/Arg homozygous subjects and Arg/Gln heterozygous individuals showed a significantly higher urinary inorganic As percentage and lower 8-OHdG concentrations than Gln/Gln homozygous. Our results suggested that Arg399Gln is a functional SNP that may be related to DNA repair activity.
- Subjects
SINGLE nucleotide polymorphisms; ARSENIC analysis; METHYLATION; DNA repair; CACODYLIC acid
- Publication
Archives of Toxicology, 2016, Vol 90, Issue 4, p1009
- ISSN
0340-5761
- Publication type
Article
- DOI
10.1007/s00204-015-1490-0