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- Title
Bisphosphonate-induced cutaneous adverse events: the difficulty of assessing imputability through patch testing.
- Authors
Barrantes-González, Melisa; Espona-Quer, Mercè; Salas, Esther; Giménez-Arnau, Ana María
- Abstract
<bold>Background: </bold>Cutaneous adverse drug reactions (CADRs) due to bisphosphonates (BPs) have been scarcely described in the literature.<bold>Objective: </bold>To discuss the diagnostic value and limitations of cutaneous provocation tests with BPs.<bold>Methods: </bold>A descriptive case series study with a control group of CADRs due to BPs studied using patch testing from 2005 to 2010 is presented.<bold>Results: </bold>Patient 1 showed a positive D4++ with alendronate at 1% in petrolatum and D4+++ with alendronate at 1 and 0.1% in water. Patient 2 showed a positive intradermal test D3++ with alendronate at 0.1% in water. Patient 3 showed a positive patch test D4+ with ibandronate at 1% in petrolatum and D4++ with ibandronate at 1% in water, and a positive intradermal test D3+++ with ibandronate at 0.1% in water.<bold>Conclusion: </bold>Establishing a correct interpretation of a patch test reaction is difficult based just on cutaneous test results. Too high concentrations of the drug can cause irritation and too low concentrations can be responsible of false-negative test reactions.
- Publication
Dermatology (10188665), 2014, Vol 229, Issue 4, p163
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000363382