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- Title
Potentiation of central reward by localised perfusion of acetylcholine and 5-hydroxytryptamine.
- Authors
REDGRAVE, PETER; IAN HORRELL, R.
- Abstract
THERE is considerable evidence that the ascending cate-cholaminergic systems of the brain1 are involved with behaviour that is contingent on reward. Much of this evidence concerns the variables which influence intracranial self-stimulation behaviour2. Because the anatomical and neurochemical correlates of self-stimulation are specified, evaluation of the catecholamine hypothesis should ideally involve the manipulation or measurement of neurochemical activity within restricted regions of the brain. We have made a first step in determining the neurochemical code of the excitatory input to the dopaminergic systems which originate in the ventral mesencephalon (VM) and which are thought to play a part in intracranial self-stimulation3. A technique well suited for this purpose is push-pull perfusion with which exogenous putative neuro-transmitters can be administered to discrete regions of the brain by way of the perfusion medium. Using this technique it was possible to establish dose-response relationships between self-stimulation of the medial forebrain bundle (MFB), through which fibres of the catecholaminergic systems pass, and perfusion of 5-hydroxytryptamine (5-HT) or acetylcholine (ACh) in the VM.
- Publication
Nature, 1976, Vol 262, Issue 5566, p305
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/262305a0