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- Title
HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: a case-control study.
- Authors
Kinnunen, A.H.; Surcel, H-M.; Lehtinen, M.; Karhukorpi, J.; Tiitinen, A.; Halttunen, M.; Bloigu, A.; Morrison, R.P.; Karttunen, R.; Paavonen, J.
- Abstract
<bold>Background: </bold>The relationship between Chlamydia trachomatis tubal factor infertility (TFI) and the host's immunoregulatory genes was studied.<bold>Methods: </bold>Cell-mediated immune responses to C. trachomatis and chlamydial heat shock protein (CHSP60) were determined by lymphocyte proliferation assay. HLA-DQ alleles and interleukin-10 (IL-10) promoter polymorphism (-1082 A/G) were analysed in 52 TFI cases and in 61 controls by PCR.<bold>Results: </bold>HLA-DQB1 or DQA1 alleles did not significantly differ between the TFI group and the control group. However, DQA1*0102 and DQB1*0602 alleles together with IL-10 -1082AA genotype were found significantly more frequently in the TFI patients than in the controls (0.18 and 0.02 respectively; P = 0.005). Five (22%) of the 23 patients who had a positive lymphocyte proliferative response to CHSP60 were positive also for IL-10 -1082AA and for the HLA-DQA1*0102 and HLA-DQB1*0602 alleles.<bold>Conclusions: </bold>Our results reveal an association of a cellular immune response to CHSP60, HLA class II alleles and IL-10 promoter genotypes in patients with chlamydial TFI.
- Publication
Human Reproduction, 2002, Vol 17, Issue 8, p2073
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/17.8.2073