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- Title
Obstetric outcome of singleton pregnancies after IVF: a matched control study in four Dutch university hospitals.
- Authors
Koudstaal, J.; Braat, D. D. M.; Bruinse, H. W.; Naaktgeboren, N.; Vermeiden, J. P. W.; Visser, G. H. A.; Braat, D D; Vermeiden, J P; Visser, G H
- Abstract
In singleton pregnancies after IVF a high rate of preterm deliveries and an increased rate of small-for-gestational age (SGA) children in comparison to the general parturient population have been reported. However, due to differences between IVF mothers and their peers who conceived naturally, careful selection of the control group is necessary to assess whether IVF pregnancies really carry increased risks of adverse outcome. In our study 307 IVF pregnancies were compared with 307 control pregnancies after elaborate matching for an extensive number of maternal characteristics, as well as for the hospital that provided the obstetric care. Four Dutch university hospitals contributed to the study. In cases with spontaneous onset of labour, gestational age at delivery was 3 days shorter in the IVF group (275 versus 278 days, P = 0.05). The proportion of SGA was higher in the IVF group (16.2 versus 7.9%, P < 0.001). The combination of these two results denotes a distinct difference between IVF and control pregnancies. Placental weight was comparable in both groups.
- Subjects
BIRTH weight; COMPARATIVE studies; FERTILIZATION in vitro; GESTATIONAL age; LABOR (Obstetrics); MATERNAL age; RESEARCH methodology; EVALUATION of medical care; MEDICAL cooperation; PREGNANCY; PREGNANCY complications; RESEARCH; SEX distribution; SMOKING; EVALUATION research; CASE-control method; REPRODUCTIVE history; MULTIPLE human abnormalities
- Publication
Human Reproduction, 2000, Vol 15, Issue 8, p1819
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/15.8.1819