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- Title
Human infection caused by the avian influenza type A virus: a comprehensive update on its pathogenesis and recommendation for future re-occurrence.
- Authors
Emmanuel, Blessing Nkechi; Akinnawo, Ayobami Sunday; Ishaq, Abubakar Nuhu; Onuh, Kingsley; Oyewumi, Ogunmoye Akin; Seun, Ofeh Augustine; Godwin, Faith; Afolayan, Faidat Abimbola; Uthman, Hassan Alao; Zubeda, Oyiza Idris-Saeed; David, Success Chekwubechukwu
- Abstract
Background: The emergence and re-emergence of the avian influenza virus in humans, particularly the A (H5) sub-types, have persistently presented a substantial danger to human well-being. Interestingly, the avian influenza virus has remained important despite various studies on the mechanism of inter-species transmission. In part, this is due to the insufficient understanding of the virus' pathogenesis, the diagnostic challenges, and the limited knowledge about the virus' genetic makeup, which enables it to keep evolving. Given the devastating nature of this disease and the possibility of the virus triggering a pandemic, this review aims to evaluate the current strains of Type A (H5) avian influenza virus, to better understand the mechanism of its interactions with humans, and to address critical questions related to its epidemiology. We further explored the factors contributing to the severity of the infection, which may improve the diagnosis and therapeutic options employed in the treatment of this disease.
- Subjects
AVIAN influenza A virus; PATHOGENESIS; PANDEMICS; ZOONOSES; WELL-being
- Publication
Microbes & Infectious Diseases, 2024, Vol 5, Issue 1, p101
- ISSN
2682-4132
- Publication type
Article
- DOI
10.21608/MID.2023.223619.1568