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- Title
МЕТАБОЛИТЕН СИНДРОМ И ЯЙЧНИКОВА ПОЛИКИСТОЗА.
- Authors
Табакова, Николета Г.
- Abstract
Polycystic ovary syndrome is a heterogeneous endocrine pathology affecting up to 10-15% of women of reproductive age and is one of the leading causes of infertility in developed countries. Polycystic ovary syndromeе is associated with many metabolic symptoms, such as obesity, insulin resistance, and hyperandrogenism. Pathogenesis of these metabolic manifestations is still not fully understood. This can be explained by multiple factors, including genetic, environmental and lifestyle factors. Polycystic ovary syndrome also shows heterogeneity in metabolic disorders as well. This supports the hypothesis of the influence of daily lifestyle and diet as well as generated metabolites on the pathogenesis of Polycystic ovary syndrome. Irving F. Stein and Michael L. Leventhal first identified this syndrome in 1935 based on the simultaneous presence of polycystic ovaries and anovulation. The diagnosis of Pоlycystic ovary syndrome is based on three criteria, which are: Rotterdam 2003, Androgen Excess and Polycystic ovary syndrome Society 2006, and National Institutes of Health Consensus 2012. Among these criteria, the Rotterdam criteria are the most extensive and widely used. According to these criteria, the diagnosis is based on three features: clinical or biochemical hyperandrogenism or both, oligo-anovulation, and polycystic ovary morphology (ultrasound examination showing the presence of ≥12 follicles with a maximum diameter of 2 –9 mm or any ovarian volume >10 mL). Patients with Polycystic ovary syndrome must meet at least two of the three criteria and other causes of hyperandrogenism, such as non-classical congenital adrenal hyperplasia, hyperprolactinemia, and hyperthecosis, must be excluded. Metabolic syndrome is a group of at least three of five cardiometabolic disorders that occur simultaneously. These include abdominal obesity, hyperglycemia, hypertriglyceridemia, low high-density cholesterol and hypertension. In practice, the body mass index, graded according to the criteria of the World Health Organization, is widely used to assess obesity. Metabolic syndrome and polycystic ovary syndrome are interrelated conditions in which excess androgens are thought to initiate a vicious cycle of metabolic disturbances in patients with polycystic ovary syndrome. This article aims to focus attention on the precise assessment of the components of the metabolic syndrome in patients with proven polycystic ovary syndrome and thus to identify patients with increased cardiometabolic risk and the appointment of appropriate lifestyle changes and possibly therapeutic interventions.
- Publication
Knowledge: International Journal, 2023, Vol 56, Issue 3, p273
- ISSN
2545-4439
- Publication type
Article