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- Title
The immune contexture in human tumours: impact on clinical outcome.
- Authors
Fridman, Wolf Herman; Pagès, Franck; Sautès-Fridman, Catherine; Galon, Jérôme
- Abstract
Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.
- Subjects
TUMOR immunology; TUMOR growth; HEALTH outcome assessment; CELLULAR immunity; EPITHELIAL cells; PROGNOSIS
- Publication
Nature Reviews Cancer, 2012, Vol 12, Issue 4, p298
- ISSN
1474-175X
- Publication type
Opinion
- DOI
10.1038/nrc3245