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- Title
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
- Authors
Yang, Qi; Li, Fengyin; Harly, Christelle; Xing, Shaojun; Ye, Longyun; Xia, Xuefeng; Wang, Haikun; Wang, Xinxin; Yu, Shuyang; Zhou, Xinyuan; Cam, Maggie; Xue, Hai-Hui; Bhandoola, Avinash
- Abstract
The cellular and molecular events that drive the early development of innate lymphoid cells (ILCs) remain poorly understood. We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors. Using novel reporter mice, we identified a new subset of early ILC progenitors (EILPs) expressing high amounts of TCF-1. EILPs lacked efficient T and B lymphocyte potential but efficiently gave rise to NK cells and all known adult helper ILC lineages, indicating that they are the earliest ILC-committed progenitors identified so far. Our results suggest that upregulation of TCF-1 expression denotes the earliest stage of ILC fate specification. The discovery of EILPs provides a basis for deciphering additional signals that specify ILC fate.
- Subjects
BONE marrow; TRANSCRIPTION factors; LYMPHOCYTES; PROGENITOR cells; KILLER cells; LABORATORY mice; PROTEIN expression
- Publication
Nature Immunology, 2015, Vol 16, Issue 10, p1044
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.3248