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- Title
Soluble c-Met protein as a susceptible biomarker for gastric cancer risk: A nested case-control study within the Korean Multicenter Cancer Cohort.
- Authors
Yang, Jae Jeong; Yang, Ji Hyun; Kim, Jungkon; Ma, Seung Hyun; Cho, Lisa Y.; Ko, Kwang‐Pil; Shin, Aesun; Choi, Bo Youl; Kim, Hyun Ja; Han, Dong Soo; Eun, Chang Soo; Song, Kyu Sang; Kim, Yong Sung; Chang, Soung‐Hoon; Shin, Hai‐Rim; Kang, Daehee; Yoo, Keun‐Young; Park, Sue K.
- Abstract
This study was conducted to evaluate the relevance of the soluble form of c-Met protein, a truncated form of the c-Met membrane receptor involved in the CagA pathway, as a potential biomarker for gastric cancer. Among 290 gastric cancer case-control sets selected from the Korean Multicenter Cancer Cohort, the plasma concentrations of soluble c-Met protein were measured with enzyme-linked immunosorbent assays. Using analysis of variance and covariance models with age, sex, smoking, Helicobacter pylori infection, and CagA seropositivity, the mean concentrations of soluble c-Met protein between cases and controls were compared. To evaluate the association between gastric cancer and a c-Met protein level, odds ratios and 95% confidence intervals were estimated using conditional logistic regression models. Interactions between CagA-related genes and the soluble c-Met protein concentration were also investigated. The overall median plasma concentration of soluble c-Met among cases was significantly lower than those of controls (1.390 vs. 1.610 ng/mL, p < 0.0001). Closer to the onset of gastric cancer, the soluble c-Met protein level decreased linearly in a time-dependent manner ( p for trend = 0.0002). The combined effects between the CagA-related genes and the soluble c-Met protein concentration significantly intensified risks for gastric cancer. Restricted analyses including cases that had been diagnosed within 1 year after entering the cohort had a fair degree of ability (area under the receiver operating characteristic curve of 0.73-0.77) to discriminate gastric cancer cases from normal controls. Our findings demonstrate the potential of the soluble form of c-Met protein as a novel biomarker for gastric cancer. The beneficial effects of a high soluble c-Met concentration in human plasma are strongly supported.
- Publication
International Journal of Cancer, 2013, Vol 132, Issue 9, p2148
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.27861