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- Title
Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's Sarcoma Family of Tumors.
- Authors
López-Guerrero, José Antonio; Machado, Isidro; Scotlandi, Katia; Noguera, Rosa; Pellín, Antonio; Navarro, Samuel; Serra, Massimo; Calabuig-Fariñas, Silvia; Picci, Piero; Llombart-Bosch, Antonio
- Abstract
More than 90% of all Ewing's Sarcoma Family of Tumors (ESFT) exhibit specific chromosomal rearrangements between the EWS gene on chromosome 22 and various members of the ETS gene family of transcription factors. The gene fusion type and other secondary genetic alterations, mainly involving cell cycle regulators, have been shown to be of prognostic relevance in ESFT. However, no conclusive results have been reported. We analyzed the clinicopathological significance of relevant cell cycle regulators in genetically confirmed ESFT. A total of 324 cases were analyzed for the immunohistochemical expression of p53, p21
- Publication
International Journal of Cancer, 2011, Vol 128, Issue 5, p1139
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.25424