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- Title
Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study.
- Authors
Nielsen, Lecia Møller; Olesen, Anne Estrup; Sato, Hiroe; Christrup, Lona Louring; Drewes, Asbjørn Mohr
- Abstract
The genetic influence on sensitivity to noxious stimuli (pain sensitivity) remains controversial and needs further investigation. In the present study, the possible influence of polymorphisms in three opioid receptor ( OPRM, OPRD and OPRK) genes and the catechol-O-methyltransferase ( COMT) gene on pain sensitivity in healthy participants was investigated. Catechol-O-methyltransferase has an indirect effect on the mu opioid receptor by changing its activity through an altered endogenous ligand effect. Blood samples for genetic analysis were withdrawn in a multi-modal and multi-tissue experimental pain model in 40 healthy participants aged 20-65. Seventeen different single nucleotide polymorphisms in different genes ( OPRM, OPRK, OPRD and COMT) were included in the analysis. Experimental pain tests included thermal skin stimulation, mechanical muscle and bone stimulation and mechanical, electrical and thermal visceral stimulations. A cold pressor test was also conducted. DNA was available from 38 of 40 participants. Compared to non-carriers of the COMT rs4680A allele, carriers reported higher bone pressure pain tolerance threshold (i.e. less pain) by up to 23.8% ( p < 0.015). Additionally, carriers of the C allele ( CC/ CT) of OPRK rs6473799 reported a 30.4% higher mechanical visceral pain tolerance threshold than non-carriers ( TT; p < 0.019). For the other polymorphisms and stimulations, no associations were found (all p > 0.05). In conclusion, COMT rs4680 and OPRK rs6473799 polymorphisms seem to be associated with pain sensitivity. Thus, the findings support a possible genetic influence on pain sensitivity.
- Subjects
PAIN management; CATECHOL-O-methyltransferase; OPIOID receptors; SINGLE nucleotide polymorphisms; GENETIC testing
- Publication
Basic & Clinical Pharmacology & Toxicology, 2016, Vol 119, Issue 4, p360
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.12601