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- Title
Effect ofHibiscus rosa sinensisExtract on Hyperproliferation and Oxidative Damage Caused by Benzoyl Peroxide and Ultraviolet Radiations in Mouse Skin.
- Authors
Sharma, Sonia; Sultana, Sarwat
- Abstract
The present study was conducted to investigate the ameliorative potential ofHibiscus rosa sinensisextract in mice skin. Combination of a single topical application of benzoyl peroxide (20 mg/0.2 ml/animal) followed by ultraviolet radiations (0.420 J/m2/s) was used to induce hyperproliferation and oxidative stress. Single benzoyl peroxide application prior to ultraviolet B radiations exposure caused significant depletion in the detoxification and antioxidant enzymes, while malondialdehyde formation, hydrogen peroxide content, ornithine decarboxylase activity and DNA synthesis were raised significantly. However, pretreatment ofH. rosa sinensisextract (3.5 mg and 7 mg/ kg b.wt.) partly restored the levels of cellular protective enzymes (P<0.05). Besides, malondialdehyde formation and hydrogen peroxide content (P<0.05) were statistically significantly reduced at both doses. The ornithine decarboxylase activity and thymidine incorporation in DNA were also reduced dose dependently (P<0.05) by the plant extract. Therefore, we propose thatH. rosa sinensisextract exerts a protective effect against the tumour promotion stage of cancer development.
- Subjects
SKIN; DEOXYRIBOSE; GENES; ENZYMOLOGY; ULTRAVIOLET radiation; PROTEINS
- Publication
Basic & Clinical Pharmacology & Toxicology, 2004, Vol 95, Issue 5, p220
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2004.pto950504.x