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- Title
Cost-Effectiveness of Asthma Step-Up Therapy as an Increased Dose of Extrafine-Particle Inhaled Corticosteroid or Add-On Long-Acting Beta-Agonist.
- Authors
Roche, Nicolas; Colice, Gene; Israel, Elliot; Martin, Richard; Dorinsky, Paul; Postma, Dirkje; Guilbert, Theresa; Grigg, Jonathan; Aalderen, Willem; Barion, Francesca; Hillyer, Elizabeth; Thomas, Victoria; Burden, Anne; Brett McQueen, R.; Price, David
- Abstract
Introduction: Data from different healthcare systems on relative cost-effectiveness of asthma step-up therapy strategies are required to inform decision-makers and clinicians. Our objective was to compare cost-effectiveness from the United Kingdom National Health Service perspective of three step-up strategies for patients with asthma uncontrolled by inhaled corticosteroid (ICS) monotherapy. Methods: This was a historical matched cohort cost-effectiveness analysis of anonymized medical records for patients with asthma of age 12-80 years. We conducted two-way comparisons of step-up therapy using increased dose (≥50%) of extrafine-particle ICS or add-on long-acting β-agonist (LABA) via fixed-dose combination (FDC) ICS/LABA inhaler or via separate inhaler. The incremental cost-effectiveness ratio (ICER) was calculated using asthma-related direct costs during one outcome year and a composite measure of risk-domain asthma control (no asthma-related hospital attendance, acute oral corticosteroids, or consultation for lower respiratory tract infection). Results: Patients prescribed ICS dose step-up ( n = 3036) had significantly lower baseline-adjusted, mean asthma-related healthcare costs during the outcome year than those prescribed FDC ICS/LABA ( n = 3036; mean difference, £124/year). ICS dose step-up had 56% probability of being less costly and marginally less effective (a trade-off), with ICER of £51,449 per additional patient controlled with FDC; and ICS dose step-up had 44% probability of being the preferred treatment strategy (less costly and more effective). In a second comparison, ICS step-up ( n = 3232) had 100% probability of being cheaper and more effective than adding LABA to ICS via separate inhalers ( n = 6464). Conclusion: For asthma step-up therapy, increasing ICS dose using extrafine-particle ICS is significantly less costly from the payer perspective and marginally (non-significantly) less effective than FDC ICS/LABA therapy containing standard fine-particle ICS. These findings apply primarily to the UK healthcare system but warrant consideration when developing guidelines in settings with strong economic constraints. Trial Registration: ClinicalTrials.gov identifier: NCT01697722. Funding: Teva Pharmaceuticals Limited, Petach Tikva, Israel.
- Subjects
ASTHMA; BECLOMETHASONE dipropionate; BUDESONIDE; CORTICOSTEROIDS; FLUTICASONE propionate; SALMETEROL
- Publication
Pulmonary Therapy, 2016, Vol 2, Issue 1, p73
- ISSN
2364-1746
- Publication type
Article
- DOI
10.1007/s41030-016-0014-2