We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Crystal structure of the <italic>MSMEG_4306</italic> gene product from <italic>Mycobacterium smegmatis</italic>.
- Authors
Kumar, Adarsh; Karthikeyan, Subramanian
- Abstract
The <italic>MSMEG_4306</italic> gene from <italic>Mycobacterium smegmatis</italic> encodes a protein of unknown function with 242 amino‐acid residues that contains a conserved zinc‐ribbon domain at its C‐terminus. Here, the crystal structure of MSMEG_4306 determined by the single‐wavelength anomalous dispersion method using just one zinc ion co‐purified with the protein is reported. The crystal structure of MSMEG_4306 shows a coiled‐coil helix domain in the N‐terminal region and a zinc‐ribbon domain in the C‐terminal region. A structural similarity search against the Protein Data Bank using MSMEG_4306 as a query revealed two similar structures, namely CT398 from <italic>Chlamydia trachomatis</italic> and HP0958 from <italic>Helicobacter pylori</italic>, although they share only ∼15% sequence identity with MSMEG_4306. Based on comparative analysis, it is predicted that MSMEG_4306 may be involved in secretion systems, possibly by interacting with multiple proteins or nucleic acids.
- Subjects
CRYSTAL structure; MYCOBACTERIUM smegmatis; CHLAMYDIA trachomatis
- Publication
Acta Crystallographica: Section F, Structural Biology Communications, 2018, Vol 74, Issue 3, p166
- ISSN
2053-230X
- Publication type
Article
- DOI
10.1107/S2053230X18002236