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- Title
Relationship Between Basic Laboratory Results and Fibrosis in Chronic Hepatitis B Patients.
- Authors
Güçlü, Ertuğrul; Öğütlü, Aziz; Kösem, Mustafa; Erkorkmaz, Ünal; Karabay, Oğuz
- Abstract
Objectives: Liver biopsy (LB) is an important cornerstone in decision to start treatment for chronic hepatitis B (HB). Viral load and liver function tests are performed to determine the most appropriate time. In this study, factors affecting liver fibrosis in hepatitis B e antigen (HBeAg) negative chronic hepatitis B patients were investigated. Materials and Methods: LB and the other laboratory results such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and hepatitis B virus (HBV)-DNA were collected from patient files, retrospectively According to study protocol, necroinflammatory scores ≤4 and fibrosis scores ≤1 were accepted as normal liver (NL), and the high value in one of these scores was accepted as chronic hepatitis (CH). Results: A total of 234 patient's LBs included in the study A total of 74 (31.6%) patients' LB was evaluated as NL. In univariate analysis, age, gender, ALT, AST, GGT, AFP and HBV-DNA >100.000 IU/mL, and in multivariate analysis, age, AST level >29 U/L, and AFP level >2.5 ng/mL were the independent risk factors for CH. Conclusion: According to our results, age, AST and AFP predict CH. Doctors who follow up chronic hepatitis B patients should be carefully evaluate these parameters when giving LB decision.
- Subjects
AGE distribution; ALPHA fetoproteins; ASPARTATE aminotransferase; CLINICAL pathology; DNA; INFLAMMATION; LIVER; LIVER function tests; MEDICAL records; MULTIVARIATE analysis; NECROSIS; NEEDLE biopsy; RISK assessment; SEX distribution; STATISTICS; VIRAL load; FIBROSIS; ALANINE aminotransferase; PREDICTIVE tests; CHRONIC hepatitis B; ACQUISITION of data methodology; DISEASE risk factors
- Publication
Viral Hepatitis Journal / Viral Hepatit Dergisi, 2019, Vol 25, Issue 2, p45
- ISSN
1307-9441
- Publication type
Article
- DOI
10.4274/vhd.galenos.2019.2019.0010