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- Title
High-dose Cepharanthin for pediatric chronic immune thrombocytopenia in Japan.
- Authors
Yamazaki, Taro; Shibuya, Atsushi; Ishii, Saori; Miura, Nobuyuki; Ohtake, Akira; Sasaki, Nozomu; Araki, Ryuichiro; Ota, Yatio; Fujiwara, Mitsuhiro; Miyajima, Yuji; Uetake, Kimiaki; Hamahata, Keigo; Kato, Koji; Kawakami, Kiyoshi; Toyoda, Hidemi; Moriguchi, Naohiko; Okada, Masahiko; Nishi, Masanori; Ogata, Yoshiyasu; Takimoto, Tomohito
- Abstract
Background A nationwide, multicenter and observational study was retrospectively conducted to evaluate the clinical utility of Cepharanthin ( CEP) for pediatric patients with chronic immune thrombocytopenia ( ITP). Methods Clinical and laboratory data for 46 Japanese patients aged <16 years who were diagnosed as having chronic ITP in 14 hospitals during 2001-2011, and were treated with CEP for >12 months, were analyzed. Results Median daily CEP dose was 1 mg/kg (range, 0.12-2 mg/kg). Median platelet count prior to CEP was 20.5 × 109/L ( IQR, 8.3-53.0 × 109/L), and then significantly increased to 58.5 × 109/L ( IQR, 22.8-115.0 × 109/L) and 69.0 × 109/L ( IQR, 23.0-134.0 × 109/L) at 12 and 24 months of treatment, respectively. No life-threatening bleeds or moderate-severe adverse events were reported. Of 38 patients who received both corticosteroids ( CS) and CEP, 17 patients (45%) were weaned from CS, and 15 patients (39%) attained the reduced dose of CS. The duration from the start of CEP to the stopping of CS was a median of 413 days (range, 49-1734 days) in patients who were weaned from CS. Conclusions CEP alone or combined with CS was useful for the management of pediatric chronic ITPs.
- Subjects
JAPAN; THERAPEUTIC use of alkaloids; ADRENOCORTICAL hormones; ALKALOIDS; CHRONIC diseases; MEDICAL cooperation; SCIENTIFIC observation; PEDIATRICS; RESEARCH; THROMBOPENIC purpura; TREATMENT effectiveness; RETROSPECTIVE studies; TREATMENT duration; DESCRIPTIVE statistics; PLATELET count
- Publication
Pediatrics International, 2017, Vol 59, Issue 3, p303
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1111/ped.13151