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- Title
Effect of PDGF-BB and beta-tricalcium phosphate (β- TCP) on bone formation around dental implants: a pilot study in sheep.
- Authors
Choo, Tina; Marino, Victor; Bartold, P. Mark
- Abstract
Objectives The aim of this investigation was to examine the effect of a combination of purified recombinant human platelet-derived growth factor (rh PDGF-BB) mixed with a synthetic beta-tricalcium phosphate (β- TCP) on bone healing around dental implants with critical size circumferential defects. Material and methods Three critical size circumferential defects were prepared in the ilium of six sheep. Three dental implants were placed into the centre of each defect and the 3.25 mm circumferential gap was filled with (a) blood clot alone; (b) β- TCP; (c) rh PDGF-BB (0.3 mg/ml) with β- TCP. All the defects in each group were covered with a Bio- Gide® resorbable barrier membrane. The sheep were sacrificed at 2 and 4 weeks and histological and histomorphometric analyses were performed to determine the percentage of new mineralized bone formation and residual β- TCP graft particles in the defects. Results Defects filled with rh PDGF-BB/β- TCP showed the highest rate of bone formation after 2 and 4 weeks with limited degradation of the β- TCP particles over 4 weeks. Defects filled with β- TCP showed the least bone fill after 2 and 4 weeks, and faster degradation of the β- TCP particles over 4 weeks compared with defects filled with rh PDGF-BB/β- TCP. Percentage of new mineralized bone was comparable in defects to blood clot alone and β- TCP after 4 weeks of healing, but there was a collapse in the defect area in defects with blood clot alone. In comparison, the space was maintained when β- TCP was used in defects at 4 weeks. Conclusions Defects which had β- TCP alone showed an inhibition in bone healing at 2 and 4 weeks; however, the combination of rh PDGF- BB with β- TCP enhanced bone regeneration in these peri-implant bone defects at the same time intervals.
- Subjects
PLATELET-derived growth factor; CALCIUM phosphate; DENTAL implants; BONE growth; HISTOLOGY; BONE grafting; BLOOD coagulation
- Publication
Clinical Oral Implants Research, 2013, Vol 24, Issue 2, p158
- ISSN
0905-7161
- Publication type
Article
- DOI
10.1111/j.1600-0501.2011.02345.x