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- Title
Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing.
- Authors
Chen, Yue-Hua; Rao, Zhou-Feng; Liu, Yu-Jie; Liu, Xiang-Sheng; Liu, Yu-Fei; Xu, Lan-Ju; Wang, Ze-Qi; Guo, Jing-Yue; Zhang, Lin; Dong, Yun-Sheng; Qi, Chun-Xiao; Yang, Chao; Wang, Shu-Fang; Moseley, Ryan
- Abstract
Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing is desiderated with the function of promoting revascularization and anti-bacteria. Herein, a multifunctional injectable composite hydrogel was prepared by incorporation of the cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG was synthesized by combining sol-gel method with template method, which maintained spherical shape, chemical structure and phase constitution of bioactive glass (BG). The Ce-BG/GelMA hydrogels had good cytocompatibility, promoted endothelial cells migration and tube formation by releasing Si ion. In vitro antibacterial tests showed that 5 mol % CeO2-containing bioactive glass/GelMA (5/G) composite hydrogel exhibited excellent antibacterial properties. In vivo study demonstrated that the 5/G hydrogel could significantly improve wound healing in diabetic rats by accelerating the formation of granulation tissue, collagen deposition and angiogenesis. All in all, these results indicate that the 5/G hydrogel could enhance diabetic wound healing. Therefore, the development of multifunctional materials with antibacterial and angiogenic functions is of great significance to promote the repair of diabetic wound healing.
- Subjects
HYDROGELS; BIOACTIVE glasses; WOUND healing; DIABETIC foot; GRANULATION tissue; NANOPARTICLES
- Publication
Biomolecules (2218-273X), 2021, Vol 11, Issue 5, p702
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom11050702