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- Title
Austronesian origin of the 27-bp deletion of the erythrocyte band 3 gene in East Sepik, Papua New Guinea inferred from mtDNA analysis.
- Authors
Tsukahara, Takahiro; Hombhanje, Francis Wanak; Koji Lum, Jeffrey; Hwaihwanje, Ilomo; Masta, Andrew; Kaneko, Akira; Kobayakawa, Takatoshi
- Abstract
The 27-bp deletion in the erythrocyte band 3 gene (B3Δ27) constitutes a genetic basis for Southeast Asian and Melanesian ovalocytosis. The distribution of B3Δ27 has been interpreted to reflect malaria selection or dispersal of the recent expansion of Austronesian-speaking populations. To explore these two hypotheses, we examined eight malarious populations of the East Sepik Province of Papua New Guinea (PNG) that speak both the Austronesian and Papuan languages. The B3Δ27 allele frequencies within populations were not positively correlated with malaria endemicities. In contrast, statistically significant geographical variations in the B3Δ27 allele distribution were observed. B3Δ27 was high (0.06–0.07) in the islands, intermediate (0.02–0.03) in coastal regions, but was absent or rare (0.00–0.01) in inland populations. Furthermore, the prevalence of the mitochondrial DNA region V 9-bp deletion, associated with the Austronesian expansion, was significantly correlated with that of B3Δ27. These results suggest that B3Δ27 was introduced by Austronesian-speaking people within the past 3,500 years and susequently expanded to populations along the coasts and islands of PNG. This study highlights the contribution of population origins, patterns of gene flow, disease selection and genetic drift in determining the genetic compositions of present populations.
- Subjects
PAPUA New Guinea; EAST Sepik Province (Papua New Guinea); MESSENGER RNA; GENETIC mutation; GENETICS
- Publication
Journal of Human Genetics, 2006, Vol 51, Issue 3, p244
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s10038-005-0352-7