We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cytopathological results of initial endoscopic ultrasound‐guided fine needle aspiration for primary mass and prognosis in pancreatic cancer patients.
- Authors
Lee, Jung Hwan; Woo, Sang Myung; Hong, Eun Kyung; Park, Sang‐Jae; Han, Sung‐Sik; Kim, Tae Hyun; Lee, Ju Hee; Lee, Woo Jin
- Abstract
Objectives: Clinical outcomes remain unclear in patients suspected of having pancreatic cancer with indeterminate endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) results. This work aimed to investigate the prognosis of pancreatic cancer patients with indeterminate findings at initial EUS‐FNA. Methods: Findings in all patients who underwent EUS‐FNA for suspected pancreatic cancer between 2008 and 2015 at the National Cancer Center, Korea, were retrospectively reviewed. A final diagnosis of pancreatic ductal adenocarcinoma was based on pathology reports. Results: Of the 144 patients evaluated, 113 (78%) were diagnosed as being positive/suspicious for malignancy on cytological evaluation and 31 (22%) as having atypia/negative/non‐diagnostic findings at initial EUS‐FNA but subsequently diagnosed with pancreatic ductal adenocarcinoma. Tumour size, clinical stage and treatment modalities did not differ significantly between these two groups. Median overall survival was significantly shorter in patients diagnosed (11.3 ± 0.74 months; 95% confidence interval [CI], 9.4‐12.8 months) than non‐diagnosed (16.9 ± 2.34 months; 95% CI, 12.0‐17.4 months) on initial EUS‐FNA (P = .024). Multivariate Cox regression analysis showed that a non‐diagnosis on initial EUS‐FNA was independently associated with better overall survival (hazard ratio, 0.58; 95% CI, 0.38‐0.88; P = .011). Conclusions: Non‐diagnostic results on initial EUS‐FNA of a primary mass may be associated with better prognosis in patients with pancreatic cancer. Clinical outcomes remain unclear in patients suspected of having pancreatic cancer with indeterminate endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) results. Our work shows that the prognosis of pancreatic cancer patients can be predicted by indeterminate findings at initial EUS‐FNA
- Subjects
PANCREATIC cancer; ENDOSCOPIC ultrasonography; ADENOCARCINOMA; PROGNOSIS; CYTOLOGY
- Publication
Cytopathology, 2019, Vol 30, Issue 2, p173
- ISSN
0956-5507
- Publication type
Article
- DOI
10.1111/cyt.12675