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- Title
Meningococcal disease: A paradigm of type‐IV pilus dependent pathogenesis.
- Authors
dos Santos Souza, Isabel; Maïssa, Nawal; Ziveri, Jason; Morand, Philippe C.; Coureuil, Mathieu; Nassif, Xavier; Bourdoulous, Sandrine
- Abstract
Neisseria meningitidis (meningococcus) is a Gram‐negative bacterium responsible for two devastating forms of invasive diseases: purpura fulminans and meningitis. Interaction with both peripheral and cerebral microvascular endothelial cells is at the heart of meningococcal pathogenesis. During the last two decades, an essential role for meningococcal type IV pili in vascular colonisation and disease progression has been unravelled. This review summarises 20 years of research on meningococcal type IV pilus‐dependent virulence mechanisms, up to the identification of promising anti‐virulence compounds that target type IV pili.
- Subjects
MENINGOCOCCAL infections; NEISSERIA meningitidis; PATHOLOGY; GRAM-negative bacteria; HEART cells; DISEASE progression
- Publication
Cellular Microbiology, 2020, Vol 22, Issue 4, p1
- ISSN
1462-5814
- Publication type
Article
- DOI
10.1111/cmi.13185