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- Title
Antitumor effects of baculovirus-infected dendritic cells against human pancreatic carcinoma.
- Authors
Fujihira, A; Suzuki, T; Chang, M O; Moriyama, T; Kitajima, M; Takaku, H
- Abstract
Recently, we showed that baculovirus (BV)-infected dendritic cells (DCs) (BV-DCs) induced antitumor immunity against established tumors in mice. These antitumor effects were CD8+ T-cell and natural killer (NK) cell dependent but CD4+ T-cell independent. In the current study, we examined the antitumor effect of BV-DCs on human pancreatic cancer cells (AsPC-1). After treatment with BV-infected bone marrow-derived dendritic cells (BMDCs), human pancreatic tumors caused by AsPC-1 cells in a nude mouse model were significantly reduced in size, and the survival of the mice was improved compared with that of non-immature BMDC (iDC)- and BV-DC-immunized mice. We also found that wild-type BV could activate human DCs (HDCs) and that NK cells were activated by BV-infected HDCs (BHDCs). Our findings show that BV-DCs can induce antitumor immunity, which paves the way for the use of this technique as an effective tool for DC immunotherapy against malignancies.
- Subjects
ANTINEOPLASTIC agents; BACULOVIRUS diseases; DENDRITIC cells; PANCREATIC cancer; IMMUNOTHERAPY; CANCER cells
- Publication
Gene Therapy, 2014, Vol 21, Issue 9, p849
- ISSN
0969-7128
- Publication type
Article
- DOI
10.1038/gt.2014.59