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- Title
A REVIEW ON PRODRUG.
- Authors
Jadhav, Kiran B.; Khirnar, Harsha R.; Ishi, Harshada S.; Borse, S. L.; Borse, L. B.; Pawar, S. P.
- Abstract
A prodrug is a precursor chemical compound of a drug. Instead of administering a drug, a prodrug might be used instead to improve how a medicine is absorbed, distributed, metabolized, and excreted (ADME).A prodrug may be used to improve how selectively the drug interacts with cells or processes that are not its intended target. It is estimated that about 10% of the drugs approved worldwide can be classified as prodrugs. Prodrugs, which have no or poor bio-logical activity, are chemically modified versions of a pharmacologically active agent, which must undergo transformation in vivo to release the active drug. Prodrugs are bio reversible derivatives of drug molecules that undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert the desired pharmacological effect. In both drug discovery and development, prodrugs have become an established tool for improving physicochemical, biopharmaceutical or pharmacokinetic properties of pharmacologically active agents. It is estimated that about 10% of the drugs approved worldwide can be classified as prodrugs. Prodrugs can also improve drug targeting, and the development of a prodrug of an existing drug with improved properties may represent a life-cycle management opportunity. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. The purpose of this article is to provide a concise overview of this modern prodrug approach.
- Subjects
CHEMICAL precursors; CHEMICALS; MOLECULAR physics; ANTIBODY-directed enzyme prodrug therapy; CARCINOGENS
- Publication
Pharma Science Monitor, 2015, Vol 6, Issue 2, p103
- ISSN
0976-9242
- Publication type
Article